PORTFOLIO COMPANIES

OVERVIEW Multi-planar expandable interbody spinal fusion system. Low profile design for safe insertion. Restores height and sagittal balance.  Expansion provides superior bone densification and reduces subsidence.

STATUS Currently supporting human clinical cases (510k cleared, 3 issued patents).

SURGEON TEAM Drs. Eastlack, Bruffey, Bawa

MARKET $2.3B global interbody fusion market by 2023 with lumbar fusion ~30% of total market.

POTENTIAL EXIT Seeking corporate strategic partners for distribution and/or acquisition.

SPINE INNOVATION

JOINT PURIFICATION SYSTEMS

OVERVIEW Novel therapeutic platform for treatment of orthopedic infection. Initial candidate is a drug/device combination system that resolves periprosthetic joint infection (PJI) in 7 days using local delivery of high concentration antibiotics via an implantable prosthesis.

STATUS Clinical stage – Phase 3 (Completed Phase II trial, 6 issued patents)

SURGEON TEAM  Drs. DeBeaubien, Chen, Parvizi, Springer and Gehrke

MARKET  $1.8B+ initial addressable U.S. market for PJI plus significant pull-through business.

POTENTIAL EXIT Acquisition by major orthopedic company.

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MEDULOC

OVERVIEW  Intermedullary fixation system for the treatment of small, long-bone fractures (fingers, feet, clavicle, radius, fibula, and ulna). Superior fracture reduction, fixation and rotational stability. Minimally invasive, soft tissue sparing surgical approach.

STATUS  Raising $1M to complete 510(k) clearance & initial alpha launch. Completed pre-submission FDA meeting, One issued patent with several pending.

SURGEON TEAM  Drs. Hustedt, Champagne, Rosenwasser

MARKET  $329M addressable market that is quickly growing.

POTENTIAL EXIT  Seeking corporate strategic partners for distribution and/or acquisition.

DELTA ORTHOPEDICS

OVERVIEW  Simple, easy-to-use hinge knee system significantly reducing morbidity in treating distal femoral fractures. Standardized technique can be integrated into major knee systems. Low COGS due to streamlined sizing, design, and instrumentation.

STATUS  Seeking corporate partner or investors to complete 510(k) clearance & initial alpha launch.  Completed cadaveric testing with fully functional implants and instrumentation, completed pre-submission FDA meeting, patent pending.

SURGEON TEAM  Drs. Barnes, Mears, Edwards, Neel

MARKET  $208M hinged knee market & $100M distal femoral fracture market. Significant pull-through from $9B total knee market.

POTENTIAL EXIT  Seeking corporate strategic partners for distribution and/or acquisition.

SAIL FUSION

OVERVIEW  Robust spinal fixation system for the treatment of Sacro-Illiac (SI) joint dysfunction.  Utilizes posterior, mini-open surgical approach. Provides direct visualization, superior decompression, and large grafting volume.

STATUS  Seeking corporate partner or investors to complete 510(k) clearance & initial alpha launch. Completed cadaveric testing with fully functional implants and instrumentation, completed pre-submission FDA meeting, 2 issued patents and several additional patents pending.

SURGEON TEAM  Drs. Patel, Bae, Whang

MARKET  $150M SI Joint fusion market (2019) with CAGR of 16%

POTENTIAL EXIT  Seeking corporate strategic partners for distribution and/or acquisition.